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Conversely, downregulated expression of fusion proteins such as optic atrophy 1 (OPA1) and mitofusin 2 (MFN2) impairs mitochondrial network connectivity and compromises energy transfer efficiency
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Recognizing that therapy is time-phased, “Combination and sequential therapies based on ROS tuning” section operationalizes combination and sequential strategies based on ROS tuning, defining acute/subacute/chronic windows, mechanism-guided combinations (source→sink/signal), disease archetypes, and biomarker-gated escalation/de-escalation
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