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8 8 , Reprinted with permission of the American Journal of Roentgenology

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lncRNAs can exert their roles through different mechanisms that can be summarized as described below ( MiRNAs and lncRNAs Regulating the GH/IGF1 Axis and IGF System in Cancer: Focus on Pituitary Adenoma, Osteosarcoma, and Colorectal Cancer A recent review analyzed the current knowledge on miRNAs regulating GH, IGF1, IGF2 and IGF1R in the context of body growth ( L) ( MiRNAs Regulating the GH/IGF1 Axis and IGF System in Pituitary Adenomas Several studies concerning the involvement of miRNAs in regulating the GH/IGF1 axis and the IGF system have been conducted in GH-secreting pituitary adenomas, which are characterized by GH hypersecretion and lead to gigantism in children and acromegaly in adults ( Table 1 summarizes the main findings of the studies investigating the role of miRNAs in pituitary adenomas