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Studies have shown that PICs can directly bind directly to glutamate receptors on neurons, thereby enhancing synaptic excitability, and promoting both central sensitization and NPP development (137)

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Approximately 75% of human genome is transcribed into RNAs [ FIGURE 1 Manufacturing exogenous mRNA has several benefits, primarily being more convenient, cost-effective, and final end-products not being subjected to additional regulations and scrutiny associated with genetically modified organisms [ In fact, one of the most well-known mRNA vaccines against SARS-CoV-2 has a current count of more than 13.72 billion doses administered worldwide [ mRNA design and modifications mRNA is a polymer of ribonucleotide building blocks, each composed of a ribose sugar, a phosphate group, and a nitrogenous base (adenine, guanine, uracil, or cytosine) [Figure 2) [ FIGURE 2 Nucleotide modification Nucleotides govern the dynamics of the expression of the genetic information encoded in the mRNA and they can be modified enzymatically or non-enzymatical (alkylation, oxidation or UV damage), to alter the biological properties of mRNA