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Frontiers | Glutathione: Pharmacological aspects and implications for clinical use in non-alcoholic fatty liver disease

(3) Regulation is carried out via peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), which functions as an activator for numerous nuclear receptors and transcription factors, regulating the expression of CPT-1 to increase fatty acid oxidation (Zong et al., 2002)

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A decrease in glutathione peroxidase activity has been found in the lenses of selenium-deficient rats.[71] Antioxidants: It is widely accepted that oxidative stress is a significant factor in the progression of cataractogenesis.[72–74] Oxidative stress is associated with increased reactive oxygen species and is known to accelerate cataract formation since superoxide is converted to a toxic substance, namely hydrogen peroxide