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In brain tumors, these effects may collectively enhance antitumor immunity by increasing tumor antigen exposure, promoting DAMP release and interferon signaling, and enabling activated T cells to access the central nervous system through a disrupted BBB [128]

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Lateral hypothalamus and intracerebroventricular infusions of NPY in mice were shown to suppress REM and NREM sleep with higher doses eliminating REM sleep and suppressing the number but not the duration of NREM episodes [108]