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The sequestration of the N-terminal active site cysteinyl residue in the holo-complex of the redox-active, yet FeS-binding, Grxs suggests that the cluster serves as a regulatory mechanism controlling the activity of the proteins, for instance, by increased levels of GSSG or nitrogen oxide (NO) [16,88], or that it may serve other redox-independent functions [16,89]
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137,138 In the brain, LDH is critical for lactate metabolism, 139 and neurons use lactate released by astrocytes as an energy substrate
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