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Mortality and/or cell growth inhibition was observed at high DZnep concentrations on cells actively growing, but WT MTAN protected the cells against this effect whereas D197A MTAN did not (Supplementary Fig

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In a similar study with MnSOD-overexpressor mice, MnSOD suppressed both apoptosis and proliferation, and the final outcome was therefore diminished: the number of papillomas decreased from 19 to 9 (Figure 13) [20, 178]