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In a model of NAFLD induced by HFD in genetically obese Zucker fatty rats, green tea polyphenol treatment (200 mg/kg BW, daily, 8 weeks) significantly suppressed hepatic triglyceride (TG) accumulation, and decreased cytoplasmic lipid droplet, which was associated with the significantly increased expression of AMPKα, reduced activation of ACC, and decreased expression of SREBP-1c following with diminished hepatic lipogenesis and triglycerides out flux from liver [130]
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