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Additionally, the FOXO4-p53 interaction contributes to the maintenance of senescent cells by activating the transcription of their common target gene, p21cip1, which suppresses apoptosis 36
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Several polyphenols have been shown to modulate sirtuin 1 signaling pathway and regulate key cell processes, such as cell cycle, DNA repair, protein aggregation, inflammation, and mitochondrial function [88]
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