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Toxicology Findings Repeated-dose toxicity studies in rats, dogs, and mice for up to 6 weeks across doses from 6 mcg/kg to 20 mg/kg via various routes showed excellent tolerance
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These results highlight the potential of pharmacological UFMylation inhibition as a novel and versatile strategy for glioblastoma treatment, positioning both compounds as promising therapeutic agents for targeting UFMylation-dependent pathways, not only in glioblastoma but potentially in other diseases as well
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