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In addition, HO-1, as an endoplasmic reticulum-resident protein, can be translocated to the mitochondria, where it stabilizes mitochondrial function under stress
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In the resting state, PKC exists in a “closed” conformation, with the N‐terminal pseudo substrate sequence (located in the regulatory domain) occupying the substrate‐binding groove in the C4 structural domain, keeping the enzyme inactivated [19]
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