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What is more critical, CCAAT/enhancer binding protein Ξ²/asparagine endopeptidase (C/EBPΞ²/AEP) signaling pathway, cleaving Tau and Ξ²-amyloid precursor protein in the brain and resulting in the pathogenesis of AD, was proved to have existed in the gut of AD mouse model and possess a mutual interaction with AD progression in the brain
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