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The UPR, crucial for innate and adaptive immunity, is activated in this situation, suggesting its role in regulating and maintaining the immune response in vitiligo.42 Another recent study analyzed the role of mitochondrial energy metabolism in melanocytes from vitiligo patients, finding reduced ATP production, increased proton leakage, altered expression of glycolytic enzymes, and hyperactivity of the PGC1α axis Style:NO LABEL https://i.ytimg.com/vi/tfBcRyh3-BU/maxresdefault.jpg Dr Ohirra Molecular toxicity of methotrexate in rheumatoid arthritis treatment: A novel perspective and therapeutic implications - ScienceDirect

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